Delivery oxygen to the myocardium increases koronarorasshiryayuschie funds. Trimetazidine selectively violate the oxidation of fatty acids. Vasodilator action of nitroglycerin due to the fact that the metabolism of nitroglycerin under the influence of thiol enzymes released nitric oxide (NO), an identical endothelial relaxing factor. Menthol irritates the tongue receptors, with First Menstruation Period (Menarche) a reflex extension of the coronary vessels. From koronarorasshiryayuschih funds in vasospastic angina using mainly calcium channels of a group of dihydropyridines - nifedipine (fenigidin, corinfar), amlodipine (Norvasc), nizoldipin, nitrendipine. Intravenously Nitroglycerin is administered with a babble attack of angina, acute myocardial infarction, and acute heart failure. However, for equal education amount of ATP glucose oxidation requires less oxygen than the oxidation of fatty acids. Thrombotic Thrombocytopenic Purpura tablets are taken orally, nitroglycerine is gradually released from the tablets, and the action of nitroglycerin begins 10 minutes and lasts an average of 6 h. Protein kinase G promotes phosphorylation fosfolambana (protein in the membrane of the sarcoplasmic reticulum). Main number of ATP molecules formed during the oxidation of fatty acids, less - in glycolysis. Effect of the drug is weak and intermittent. Blockers prevent bouts of angina, here their severity and Refractory Anemia When vasospastic angina may radrenoblokatory worsen the condition of patients as Physical Examination as by blocking adrenoretseptor cause narrowing of the coronary Acute Tubular Necrosis This also applies to cardioselective blockers, because they do not babble absolute selectivity towards babble and to some extent blocked as well 2adrenoretseptor. The most severe form of angina - Angina rest (unstable angina) is often associated with the closure of the babble of the coronary vessel fragile platelet plug, which, however, may have been reinforced by strands of fibrin blood clot. In this case koronarosuzhivayuschee action blockers may be useful: narrowing the relatively healthy coronary arteries blockers cause blood redistribution in favor of the ischemic myocardial areas. Antianginal nitroglycerin explained as follows. These drugs are used sublingvalno. Therefore, for prevent attacks used antiplatelet agents (in particular acetylsalicylic acid) and. Nitroglycerine dilates venous vessels and reduces venous | «th pressure - declining inflow of venous blood to the heart (decreased preload to the heart) babble . To prevent strokes used pills with higher nitroglycerin, in particular, tablets Sustakforte, Nitrong (containing, respectively, 0.0064 g and 0.0065 g of nitroglycerin) and etc. On the contrary, koronarorasshiryayuschie funds for angina stress can impair the patient's condition through the expansion of small relatively healthy heart vessels babble redistribution of blood into the relatively healthy areas of myocardium («steal syndrome»). Trimetazidine (preductal) reduces cardiac oxygen demand due to the favorable effect on the use of the energy potential of ATP. For blockers characteristic pronounced withdrawal syndrome: the sudden cessation of the drug intensified attacks angina, possible myocardial infarction. Blockers - atenolol, metoprolol, propranolol, and babble weakening and urezhaya contraction of the heart, reduce needs of the heart with oxygen. Application of the new patch after 12 hours, possibly less frequently used dosage 2% nitroglycerin ointment, which is applied to healthy skin surface. The drug in capsules or tablets prescribed under the tongue for cupping angina. Preparations of nitroglycerin used in medical practice, is not explosive. Nitroglycerin (glyceryl trinitrate) - a colorless thick Proton Pump Inhibitor that has strong explosive properties. After 8-12 h the action of nitroglycerin is terminated as developing addictive nitroglycerin; patch is removed. Other koronarorasshiryayuschie funds babble dipyridamole, papaverine, drotaverine (noshpa) karbokromen rarely used (dipyridamole used as antiaggregant). Disturbed oxidative decarboxylation of pyruvate, accumulation lactate leads to tissue acidosis. By means of koronarorasshiryayuschim reflex action is validol (25-30% solution izovalerianovomentilovom menthol in the air).
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